I didn't know that we had varieties of grapes that were native to North America. Here is a good article from a museum exhibition that goes over some of the medicinal usages they had here. Pictures too.

https://discoverandshare.org/2021/10/05/grafting-the-grape-indigenous-us...

"The American Vitis species have an ancient history of use by humans. These grapevines and berries were first harvested by the Indigenous peoples who inhabited the North American continent, and who lived or traveled through the lands that are now designated as the boundaries of the state of Missouri. Today, these native grapes are one of many native American plants that play a role in Indigenous culture and foodways, and the use of different species is documented in many diverse Native American nations.

Archaeological investigations in North America have recovered plant food remains that include grape plant seeds. Grapes appear to have been part of the Indigenous North American diet for over 10,000 years, and have been found in sites of this age, including the Dust Cave site in northwestern Alabama, which dates to the Late Paleoindian period (8500-8000 BCE)."